陳建，男，湖南沅江人，博士（後），教授，博士及碩士研究生導師，2003网站太阳集团教育部重點實驗室專職科研人員，中國化學會會員。近年來，先後共主持各類科研項目10來項。2010年獲廣東省優秀博士學位論文，2011年獲全國優秀博士學位論文提名獎，2014年獲湖南省化學化工學會第十三屆青年化學化工獎，2019年湖南省121創新人才第三層次。在《Advanced Functional Materials》、《Small》、《Macromolecules》、《Chemical Communications》、《Polymer Chemistry》等國内外雜志上發表SCI論文60餘篇，引用1800餘次，其中ESI高被引論文3篇，H指數為25。申請發明專利20餘項，授權14項。
聯系方式：Email: cj920@foxmail.com
主持的科研或教研項目：
[1] 國家自然科學基金面上項目：具有基因載體功能的光開關近紅外熒光聚合物納米材料設計合成與生物成像研究（No. 51773056），2018-2021；
[2] 國家自然科學基金面上項目：水分散性熒光聚合物量子點設計合成及多色可調光開關研究（No. 51373002），2014-2017；
[3] 國家自然科學基金青年項目：新型兩親性多色熒光聚合物納米粒子的設計合成及FRET研究（No. 51003026），2011-2013；
[4] 中國博士後科學基金特别資助項目：熒光聚合物量子點構建與硫離子比率熒光檢測及成像研究(No. 2015T80867)， 2015-2016；
[5] 中國博士後科學基金項目：新型熒光聚合物量子點制備與汞離子熒光比率檢測應用（第55批面上一等資助，No. 2014M550418），2014-2015；
[6] 教育部留學回國人員科研啟動基金：基于共轭聚合物的光開關熒光納米材料設計及FRET研究， 2014-2016；
[7] 湖南省教育廳優秀青年基金：新型兩親性光開關熒光聚合物納米粒子設計合成與優化，（No. 12B041），2012-2014；
[8] 湖南省自然科學基金青年項目：聚合物納米粒子中熒光共振能量轉移體系的構建與優化（No. 11JJ4016），2011-2013；
發表的主要論文：
1. Sheng Wang, Hong Wang, Peisheng Zhang, Lulu Xue, Jian Chen* and Jiaxi Cui*, Folding Fluorescent Probes for Self-Reporting Transesterification in Dynamic Polymer Networks. Materials Horizons , 2021, DOI: 10.1039/D0MH02024A.
2. Hui Liu, Peisheng Zhang*, Chonghua Zhang, Jian Chen* and JianHui Jiang*, Self-assembly of dual targeting and self-calibrating ratiometric polymer nanoprobe for accurate hypochlorous acid imaging. ACS Applied Materials & Interfaces , 2020, 12 (41): 45822–45829.
3. Hong Wang, Peisheng Zhang,* Chonghua Zhang, Shu Chen, Rongjin Zeng, Jiaxi Cui and Jian Chen*, A rational design of a cancer-specific and lysosome-targeted fluorescence nanoprobe for glutathione imaging in living cells. Materials Advances , 2020, 1: 1739-1744.
4. Jie Liu, Yubing Zhang, Chonghua Zhang, Peisheng Zhang, Rongjin Zeng*, Jiaxi Cui*, Jian Chen* Perylene diimide-based supramolecular polymer with temperature-sensitive ratiometric fluorescence responsiveness in solution and gels. Materials Advances , 2020, 1: 1330-1336.
5. Mingju Xue, Jian Chen*, Yubin Zhang, Le Liu, Yuqi Li, Chonghua Zhang, Peisheng Zhang*, Susanne Sihler, and Ulrich Ziener,* Dual Function of Eosin Y in Miniemulsion Polymerization: Stabilizer and FRET Acceptor. European Polymer Journal 2020, 134: 109862.
6. Hongqing Wei, Rongjin Zeng,* Shenglan Wang, Chong-Hua Zhang, Shu Chen, Peisheng Zhang* Jian Chen*, Engineering of a zero cross-talk fluorescent polymer nanoprobe for self-referenced ratiometric imaging of lysosomal hypochlorous acid in living cells. Materials Chemistry Frontiers 2020, 4(3): 862-868.
7. Junyu Ren, Peisheng Zhang*, Hui Liu, Chonghua Zhang, Shu Chen, Rongjin Zeng, Yong Gao*, Jiaxi Cui, Jian Chen*, Single-chromophore-based fluorescent nanoprobe enables self-referenced ratiometric imaging of hypochlorous acid in lyso-somes. Sensors and Actuators B 2020, 304: 127299.
8. Hong Wang1, Jing Wei1, Chonghua Zhang*, Yuan Zhang, Yubin Zhang, Lin Li, Changmin Yu*, Peisheng Zhang, Jian Chen*, Red carbon dots as label-free two-photon fluorescent nanoprobes for imaging of formaldehyde in living cells and zebrafishes. Chinese Chemical Letters , 2020, 31: 759-763.
9. Sheng Wang, Li Yang, Hong Wang, Lulu Xue, Jian Chen*, Jiaxi Cui*, Nonequilibrium Transesterification for Programming a Material's Stiffening. ACS Applied Polymer Materials 2019, 1: 3227-3232.
10. Zhong Lin1, Hong Wang1, Maolin Yu, Xiang Guo, Chonghua Zhang, Haitao Deng, Peisheng Zhang, Shu Chen, Rongjin Zeng, Jiaxi Cui*, Jian Chen*, Photoswitchable ultrahigh-brightness red fluorescent polymeric nanoparticles for information encryption, anti-counterfeiting and bioimaging. Journal of Materials Chemistry C , 2019, 7: 11515-11521.
11. Ying Liu, Chonghua Zhang*, Peisheng Zhang, Hong Wang, Jinwen Liu, Shenglan Wang, Rongjin Zeng*, Shu Chen, Jian Chen*, Block copolymer nanoparticles-based fluorescent sensor for ultrasensitive detection of tyrosinase activity and inhibitor. Sensors and Actuators B 2019, 298: 126935.
12. Hong Wang1, Yanyang He1, Yuqi Li, Chonghua Zhang, Peisheng Zhang*, Jiaxi Cui, Yunfei Long, Shu Chen, Rongjin Zeng, Jian Chen*, Selective ratiometric fluorescence detection of hypochlorite by using aggregation-induced emission dots. Analytical and Bioanalytical Chemistry , 2019, 411: 1979-1988.
13. Maolin Yu, Hong Wang, Yuqi Li, Peisheng Zhang*, Shu Chen, Rongjin Zeng, Yong Gao*, Jian Chen*, Photoswitchable diarylethene-based polyurethane film for photorewritable patterning and stable information storage. Journal of Applied Polymer Science 2019, 136(20): 47466.
14. Yongxiang Hong, Hong Wang, Mingju Xue, Peisheng Zhang*, Wanqiang Liu, Shu Chen, Rongjin Zeng, Jiaxi Cui, Yong Gao*, and Jian Chen*, Rational design of a ratiometric and lysosome-targetable AIE dots for imaging endogenous HClO in live cells. Materials Chemistry Frontiers 2019, 3: 203-208.
15. Mingju Xue1, Hong Wang1, Jian Chen*, Junyu Ren, Shu Chen, Heping Yang, Rongjin Zeng, Yunfei Long and Peisheng Zhang*, Ratiometric fluorescent sensing of endogenous hypochlorous acid in lysosomes using AIE-based polymeric nanoprobe. Sensors and Actuators B 2019, 282: 1-8.
16. Chong-Hua Zhang, Hong Wang, Jin-Wen Liu, Ying-Ying Sheng, Jian Chen*, Peisheng Zhang, Jian-Hui Jiang*, Amplified Split Aptamer Sensor Delivered Using Block Copolymer Nanoparticles for Small Molecule Imaging in Living Cells. ACS Sensors 2018, 3, 2526−2531.
17. Maolin Yu1, Peisheng Zhang1, Baiju P. Krishnan, Hong Wang, Yong Gao*, Shu Chen, Rongjin Zeng, Jiaxi Cui*, and Jian Chen*, From a Molecular Toolbox to a Toolbox for Photoswitchable Fluorescent Polymeric Nanoparticles. Advanced Functional Materials, 2018, 28: 1804759.
18. Hong Wang1, Peisheng Zhang1, Baiju P. Krishnan, Maolin Yu, Jie Liu, Mingju Xue, Shu Chen, Rongjin Zeng, Jiaxi Cui* and Jian Chen*, Switchable single fluorescent polymeric nanoparticles for stable white-light generation. Journal of Materials Chemistry C, 2018, 6: 9897-9902.
19. Peisheng Zhang*, Yong Tian, Hui Liu, Junyu Ren, Hong Wang, Rongjin Zeng, Yunfei Long and Jian Chen, In vivo imaging of hepatocellular nitric oxide using a hepatocyte-targeting fluorescent sensor, Chemical Communications, 2018, 54: 7231-7234.
20. Hong Wang, Peisheng Zhang*, Yong Tian, Yuan Zhang, Heping Yang, Shu Chen, Rongjin Zeng*, Yunfei Long, Jian Chen*. Real-time monitoring of endogenous cysteine levels in living cells using a CD-based ratiometric fluorescent nanoprobe. Analytical and Bioanalytical Chemistry, 2018, 410: 4379-4386.
21. Yongxiang Hong, Peisheng Zhang*, Hong Wang, Maolin Yu, Yong Gao*, Jian Chen*. Photoswitchable AIE nanoprobe for lysosomal hydrogen sulfide detection and reversible dual-color imaging. Sensors and Actuators B 2018, 272: 340-347.
22. Peisheng Zhang, Hong Wang, Di Zhang, Xuyao Zeng, Rongjin Zeng,* Lehui Xiao*, Hongwen Tao Yunfei Long, Pinggui Yi, and Jian Chen*. Two-photon fluorescent probe for lysosome-targetable hypochlorous acid detection within living cells. Sensors and Actuators B 2018, 255: 2223-2231.
23. Peisheng Zhang*, Hong Wang, Yongxiang Hong, Maolin Yu, Rongjin Zeng, Yunfei Long, Jian Chen*. Selective visualization of endogenous hypochlorous acid in zebrafish during lipopolysaccharide-induced acute liver injury using a polymer micelles-based ratiometric fluorescent probe. Biosensors and Bioelectronics 2018, 99: 318–324.
24. Peisheng Zhang,1 Yongxiang Hong,1 Hong Wang, Maolin Yu, Yong Gao,*, Rongjin Zeng,* Yunfei Long and Jian Chen*. Selective visualization of endogenous hydrogen sulfide in lysosomes via using aggregation induced emission dots. Polymer Chemistry 2017, 8: 7271 - 7278.
25. Jian Chen,* Weibang Zhong, Mingju Xue, Hong Wang, Maolin Yu, Peisheng Zhang* and Pinggui Yi*. Photochromic RAFT reagent helps constructing superior photoswitchable fluorescent polymer nanoparticles for rewritable fluorescence patterning and intracellular dual-color imaging. Polymer Chemistry 2017, 8: 6520-6526.
26. Hong Wang, Peisheng Zhang,* Yongxiang Hong, Bin Zhao, Pinggui Yi and Jian Chen*. Ratiometric imaging of lysosomal hypochlorous acid enabled by FRET-based polymer dots. Polymer Chemistry 2017, 8: 5795-5802.
27. Weibang Zhong1, Xuyao Zeng1, Jian Chen*, Yongxiang Hong, Lehui Xiao and Peisheng Zhang*. Photoswitchable fluorescent polymeric nanoparticles for rewritable fluorescence patterning and intracellular dual-color imaging with AIE-based fluorogens as FRET donors. Polymer Chemistry 2017, 8: 4849-4855.
28. Jian Chen*, Chonghua Zhang, Kun Lv, Hong Wang, Peisheng Zhang*, Pinggui Yi, Jianhui Jiang*. A silica nanoparticle-based dual-responsive ratiometric probe for visualizing hypochlorite and temperature with distinct fluorescence signals. Sensors and Actuators B 2017, 251: 533-541.
29. Jian Chen, Adam W. Ziegler, Baoming Zhao, Wei Wan and Alexander D. Q. Li*. Chemomechanical-force-induced folding–unfolding directly controls distinct fluorescence dual-color switching. Chemical Communications, 2017, 53, 4993-4996.
30. Hong Wang1, Peisheng Zhang1, Jian Chen*, Ya Li, Maolin Yu, Yunfei Long, Pinggui Yi. Polymer nanoparticle-based ratiometric fluorescent probe for imaging Hg2+ ions in living cells. Sensors and Actuators B 2017, 242: 818-824.
31. Kun Lv, Jian Chen*, Hong Wang, Peisheng Zhang*, Maolin Yu, Yunfei Long, Pinggui Yi. One-pot fabrication of FRET-based fluorescent probe for detecting copper ion and sulfide anion in 100% aqueous media. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2017, 177, 63-68.
32. Hong Wang, Jian Chen*, Yongxiang Hong, Kun Lv, Maolin Yu, Peisheng Zhang*, Yunfei Long, and Pinggui Yi. Fabrication of Water-soluble Fluorescent Polymeric Micelles for Selective Detection of Hg2+ in Blood Serum. Analytical Sciences 2017, 33, 591-597.
33. Jian Chen*, Ying Tang, Hong Wang, Peisheng Zhang*, Ya Li and Jianhui Jiang*. Design and fabrication of fluorescence resonance energy transfer-mediated fluorescent polymer nanoparticles for ratiometric sensing of lysosomal pH, Journal of Colloid and Interface Science 2016, 484: 298-307.
34. Jian Chen*, Ya Li, Kun lv, Weibang Zhong, Hong Wang, Zhan Wu*, Pinggui Yi* and Jianhui Jiang. Cyclam-Functionalized Carbon Dots Sensor for Sensitive and Selective Detection of Copper(II) Ion and sulfide anion in Aqueous Media and Its Imaging in Live Cells. Sensors and Actuators B 2016, 224: 298-306.
35. Jian Chen,* Ya Li, Weibang Zhong, Hong Wang, Peisheng Zhang* and Jianhui Jiang. A highly selective fluorescent and colorimetric chemosensor for Hg2+ based on a new rhodamine derivative. Analytical Methods 2016, 8: 1964-1967.
36. Jian Chen,* Weibang Zhong, Ying Tang, Zhan Wu, Ya Li, Pinggui Yi,* Jianhui Jiang*. Amphiphilic BODIPY-Based Photoswitchable Fluorescent Polymeric Nanoparticles for Rewritable Patterning and Dual-Color Cell Imaging. Macromolecules 2015, 48: 3500-3508.
37. Jian Chen*, Ya Li, Weibang Zhong, Qingyang Hou, Hong Wang, Xiang Sun and Pinggui Yi. Novel fluorescent polymeric nanoparticles for highly selective recognition of copper ion and sulfide anion in water. Sensors and Actuators B 2015, 206: 230-238.
38. Jian Chen*, Fuhua Huang, Hong Wang, Ya Li, Shengli Liu, Pinggui Yi. One-pot preparation of multicolor polymeric nanoparticles with high brightness by single wavelength excitation. Journal of Applied Polymer Science 2015, 132: 41492.
39. Bo Liao*, Peng Long, Benqiao He*, Shoujun Yi, Baoli Ou, Shaohua Shen, Jian Chen*. Reversible Fluorescence Modulation of Spiropyrans-functionalized Carbon Nanoparticles. Journal of Materials Chemistry C 2013, 1: 3716-3721.
40. Peisheng Zhang, Jian Chen*, Fuhua Huang, Zhiqiang Zeng, Jia Hu, Pinggui Yi*, Fang Zeng and Shuizhu Wu. One-pot fabrication of polymer nanoparticle-based chemosensor for Cu2+ detection in aqueous media. Polymer Chemistry 2013, 4: 2325-2332.
41. Jian Chen*, Dapeng Wang, Andrey Turshatov, Rafael Muñoz-Espí, Ulrich Ziener,* Kaloian Koynov, Katharina Landfester*. One-pot Fabrication of Amphiphilic Photoswitchable Thiophene-Based Fluorescent Polymer Dots. Polymer Chemistry 2013, 4: 773-781.
42. Jian Chen, Jie Shu, Simone Schobloch, Anja Kroeger, Robert Graf, Rafael Muñoz-Espí, Katharina Landfester, and Ulrich Ziener*. A New Design Strategy for the Synthesis of Unsubstituted Polythiophene with Defined High Molecular Weight. Macromolecules 2012, 45: 5108-5113.
43. Jian Chen*, Peisheng Zhang, Gang Fang, Chao Weng, Jia Hu, Pinggui Yi*, Xianyong Yu and Xiaofang Li. One-pot synthesis of amphiphilic reversible photoswitchable fluorescent nanoparticles and their fluorescence modulation properties. Polymer Chemistry 2012, 3: 685-693.
44. Jian Chen*, Peisheng Zhang, Gang Fang, Pinggui Yi*, Fang Zeng and Shuizhu Wu. Design and Synthesis of FRET-Mediated Multicolor and Photoswitchable Fluorescent Polymer Nanoparticles with Tunable Emission Properties. Journal of Physical Chemistry B 2012, 116(14):4354-4362.
45. Jian Chen, Peisheng Zhang, Gang Fang, Pinggui Yi*, Xianyong Yu, Xiaofang Li, Fang Zeng* and Shuizhu Wu. Synthesis and Characterization of Novel Reversible Photoswitchable Fluorescent Polymeric Nanoparticles via One-Step Miniemulsion Polymerization. Journal of Physical Chemistry B 2011, 115(13): 3354-3362.
授權發明專利：
[1]. 陳建, 李亞, 黃富華, 孫祥, 王宏, 一種具有銅離子和硫陰離子雙識别功能的水分散性熒光聚合物納米粒子及其制備方法和應用, 發明專利, 授權專利号: ZL201310322589.2。
[2]. 陳建, 鐘維邦, 孫祥, 李亞, 候慶揚, 易平貴, 一種檢測汞離子的兩親性聚合物納米粒子、制備方法及應用, 發明專利, 授權專利号: ZL201410061992.9。
[3]. 陳建, 鐘維邦, 李亞, 呂锟, 李明莉, 廖博, 易平貴, 一種兩親性光開關熒光聚合物納米粒子及其制備方法, 發明專利, 授權專利号: ZL201410352430.X。
[4]. 陳建, 王宏, 李亞, 侯慶楊, 呂锟, 吉添, 李明莉, 周智華, 易平貴,一種具有pH值和汞離子比率檢測功能的水分散性熒光聚合物納米粒子、制備方法及應用, 發明專利, 授權專利号: ZL201410369075.7。
[5]. 陳建, 李亞, 鐘維邦, 呂锟, 王宏, 廖博, 易平貴, 一種具有銅離子和半胱氨酸雙識别功能的碳量子點傳感器及其制備方法和應用, 發明專利, 授權專利号: ZL201410610062.4。
[6]. 陳建, 李亞, 王宏, 鐘維邦, 呂锟, 侯慶陽, 易平貴, 一種具有硫離子、銅離子和pH值多重檢測功能的熒光傳感器制備方法及應用, 發明專利, 授權專利号: ZL201510001105.3。
[7]. 陳建, 鐘維邦, 李亞, 呂锟, 王宏, 廖博, 易平貴, 兩親性多色光開關熒光聚合物納米粒子及其制備方法, 發明專利, 授權專利号: ZL201410776223.7。
[8]. 陳建, 李亞, 鐘維邦, 呂锟, 王宏, 侯慶陽, 易平貴, 基于羅丹明衍生物的比色汞離子傳感器的制備方法及應用, 發明專利, 授權專利号: ZL201410776232.6。
[9]. 陳建、李亞、王宏、鐘維邦、呂锟、洪永想、易平貴，一種基于聚乙二醇的硫離子傳感器及其制備方法和應用，發明專利, 授權專利号: ZL201510413193.8。
[10]. 陳建、呂锟、洪永想、鐘維邦、王宏、易平貴，一種具有多識别功能的熒光聚合物及其制備方法和應用，發明專利, 授權專利号: ZL201510425158.8。
畢業研究生情況：
2009級 張培盛（華南理工大學讀博）
2011級 黃富華（河南大學讀博）
2013級 李亞（華南理工大學讀博）
2014級 鐘維邦（湖南大學讀博）、呂锟（中外合資塗料企業）
2015級 洪永想（湖南大學讀博）
2016級 王宏（電子科技大學讀博）、餘茂林（武漢大學讀博）
2017級 劉傑（市級公務員） 任俊宇（吉林大學讀博）
