謝文林，男，1967年生，博士，教授，碩士生導師。主要從事新型抗腫瘤藥物的設計、合成和分子機理研究以及酪氨酸酶、葡萄糖苷酶、乙酰膽堿酯酶等酶抑制劑的設計合成和活性篩選。近年來主持國家自然科學基金面上項目1項、湖南省自然科學基金等省部級項目6項、藥物研發橫向課題4項。獲湖南省自然科學三等獎一項，獲省部級教學成果二等獎、三等獎各1項，指導研究生獲湖南省第八屆研究生創新論壇優秀論文一等獎1項。在Adv. Synth. Catal., J. Org. Chem., Chem.-Asian J., Eur. J. Med. Chem., Bioorg. Med. Chem. Lett., Chem. Biol. Drug Des.,J. pept. Sci.和化學學報等國内外重要刊物上共發表學術論文50餘篇，SCI收錄30餘篇。申請中國發明專利12項，授權5項。
聯系方式：Email: xwl2000zsu@163.com
研究方向：
1、類天然有機小分子的設計與合成；
2、藥物分子的設計、合成與生物活性研究；
主持的科研或教研項目：
以G-四鍊體為靶的Isatin衍生物及其金屬配合物的合成和抗癌作用（No. 21571058），國家自然科學基金， 70.0萬元, 2016,01-2019,12
發表的主要論文：
[1]. Yanfang Yao, Ziqing Yin, Weiyun Chen, Wenlin Xie,* Fu-Sheng He,b,* and Jie Wub*, A Concise Route to 2-Sulfonylacetonitriles from Sodium Metabisulfite, Advanced Synthesis & Catalysis, 2021, 363, 570–574.
[2]. Liangkun Ji, Ying Zhou, Qiuyan Yu, Yaxuan Fang, Yongjun Jiang, Yunhui Zhao, Chuntao Yuan, Wenlin Xie*, Synthesis and anticancer activity of new spirooxindoles incorporating[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine moiety, Journal of Molecular Structure, 2021, 1227, 129406-129412
[3]. Renzhi Liu, Min Yang, Wenlin Xie*, Wenbi Dong, Hongwei Zhou, Sarita Yadav, Vladimir Ivano-vich Potkin, Guanyinsheng Qiu*, Synthesis of 3-Hydroxy- isoindolin- 1-ones Through 1, 4-Dioxane-Mediated Hydroxylhydrative aza-Cycli-zation of 2-Alkynylbenzamide in Water, Journal of Organic Chemistry, 2020, 85, 5312−5320
[4]. Renzhi Liu, Meng Li, Wenlin Xie*, Hongwei Zhou*, Yajing Zhang, Guanyinsheng Qiu*, Tunable Synthesis of 3-Hydroxylisoquinolin-1, 4-dione and Isoquinolin-1-one Enabled by Copper-Catalyzed Radical 6-Endo Aza-Cyclization of 2-Alkynylbenzamide, Journal of Organic Chemistry, 2019, 84, 11763−11773
[5].Wenlin Xie*, Yiqiang Wu, Jingai Zhang, Qihong Mei, Yahan Zhang, Ning Zhu, Renzhi Liu, Huilin Zhang, Design, synthesis and biological evaluations of novel pyridone-thiazole hybrid molecules as antitumor agents, European Journal of Medicinal Chemistry, 2018, 145, 35-40
[6]. Wenlin Xie*, Huilin Zhang, Jingjing He, Jingai Zhang, Qiuyan Yu, Chunxiang Luo, Shangru Li，Synthesis and Biological Evaluation of novel hydroxybenzaldehyde-based analogues as inhibitors of mushroom tyrosinase, Bioorganic & Medicinal Chemistry Letters, 2017,27(3): 530-532
[7]. Wenlin Xie *, Jingai Zhang, Xiaojing Ma, Wenqian Yang, Ying Zhou, Xufu Tang, Yan Zou, Hui Li, Jingjing He, Shimin Xie, Yunhui Zhao, Fengping Liu,Evaluation of Kojic Acid Derivatives Containing 1,2,4-triazole as Potent Tyrosinase Inhibitors, Chemical Biology & Drug Design, 2015, 86(5): 1087–1092
[8]. Wenlin Xie*, Shimin Xie, Ying Zhou, Xufu Tang, Jian Liu, Wenqian Yang, Minghua Qiu, Design and synthesis of novel 5,6-disubstituted pyridine-2,3- dione-3-thiosemicarbazone derivatives as potential anticancer agents, European Journal of Medicinal Chemistry, 2014, 81, 22-27
[9]. Xianyong Yu*, Zhixi Liao, Qing Yao, Heting Liu, Wenlin Xie*, Spectroscopic studies on the interaction of phacolysin and bovine serum albumin, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2014, 127, 231–236
出版教材或專著：
謝文林等主編. 有機化學實驗(第二版)，湘潭大學出版社，2018
授權發明專利：
[1]. 謝文林，唐緒福，楊文前，騰珍珍, 一種5-取代-4-[5-羟基-4-吡喃酮-2-基-亞甲氨基]-3-巯基-1,2,4-**類化合物及其用途,專利号：ZL201310235619.6.
[2]. 謝文林，唐緒福, 楊文前, 5-取代-3-[5-羟基-4-吡喃酮-2-基-甲硫基]-4-氨基-1,2,4-**類化合物及其用途, 專利号：ZL201310198771.1.
[3]. 謝文林，張慧霖，餘秋豔，吳乙強，梅期宏，駱春香，一種含螺吲哚-2-酮衍生物及其制備方法和作為抗癌藥物的應用，專利号：ZL201610309985.5
[4]. 謝文林，張金改，餘秋豔，何晶晶，李芯蕊，駱春香，李尚儒，柳建斌，5-取代-3-[5-羟基-4-吡喃酮-2-基-甲硫基]-4-羟基苯甲氨基-1,2,4-**類化合物及其用途，專利号：ZL201510414130.4
[5]. 謝文林，吳乙強，梅期宏，張金改，張慧霖，劉仁志，一種含噻唑環吡啶酮衍生物及其制備方法和應用，專利号：ZL201710435688.X
