2003网站太阳集团

黃昊文

1

日期：2021-03-16發稿人：

黃昊文，男，1969年生，博士，教授，博士生導師，現任2003网站太阳集团教育部重點實驗室副主任。畢業于中國科學院化學研究所，美國德克薩斯大學聖安東尼奧分校訪問學者(2016.3-2017.3), 2009、2011年兩度赴香港城市大學進行合作研究。連續主持三項國家自然科學基金，已完成國家自然科學基金、湖南省自然科學基金、湖南省教育廳青年項目、國家重點實驗室開放課題等多項研究項目。以第一作者或通訊聯系人身份在《Biomaterials》、《Analytical Chemistry》、《Chemical Communications》、《Biosensor and Bioelectronics》、《ACS Applied Materials and Interfaces》等國際刊物上發表科研論文40餘篇。已申請國家發明專利15項，獲湖南省2016年度自然科學二等獎（排名第一）。

聯系方式：Email: hhw@hnust.edu.cn; hhwn09@163.com

研究方向

本課題組的研究方向為分析化學，生化分析，具體内容包括：

[1] 納米化學/生物傳感器的構建與應用；

[2] 高靈敏度可視化檢測方法研究

[3] 食品安全、臨床醫學分析中的試劑盒、臨床試紙研制等

獲獎情況

2016年湖南省自然科學二等獎（排名第一）

主持科研項目

[1] 國家自然科學基金項目：基于碳點及複合物模拟酶構建食品中金黃色葡萄球菌及腸毒素的現場、快速檢測方法研究（21675049），2017.01-2020.12；

[2] 國家自然科學基金項目：可控納米結構表面等離子體共振生物傳感器的構建及肝癌早期檢測研究（21375036），2014.01-2017.12；

[3] 核殼型納米棒構建生物傳感器陣列的研究（項目編号：21075035），2011.01-2013.12;

[4] 湖南省自然科學基金項目：基于雙重放大信号策略構建檢測緻病菌及毒素的高靈敏度可視化方法（2020JJ4289）, 2020.01-2023.12；

[5] 湖南省自然科學基金項目：可控金納米複合結構表面等離子體共振生物傳感器的構建研究(14JJ70054), 2014.01-2016.12;

[6] 湖南省高校創新平台開放基金項目：基于金納米棒的一維自組裝及解組裝構建生物傳感方法研究(13K090), 2014.01-2016.12;

[7] 湖南省自然科學基金項目：殼層包覆金納米棒的生物傳感器研制與應用(10JJ5004), 2010.01-2012.12;

[8] 高性能陶瓷和超微結構國家重點實驗室開放課題：核殼型納米棒構建生物傳感器的研究（SKL201006SIC）, 2011.01-2012.12；

[9] 中國科學院特種無機塗層重點實驗室開放課題：基于核殼型納米粒子的表面等離子體共振性質構建多通量表面分析方法的研究（KLICM-2011-09），2012.01-2013.12；

[10] 固體表面物理化學國家重點實驗室：基于金納米棒的表面分析新方法研究鈣調神經磷酸酶與藥物的相互作用，2008.01-2009.12；

[11] 湖南省教育廳優秀青年項目：新型生物傳感器—表面等離子體共振成像儀的研制（06B28），2007.01-2009.12。

代表性論文（2011年以後）：

[1] Xiaoxue Xie, Xinyi Hua, Ziqi Wang, Xiumei Yang, Haowen Huang*. Real-Time Imaging Redox Status in Biothiols and Ferric Metabolism of Cancer Cells in Ferroptosis Based on Switched Fluorescence Response of Gold Carbon Dots, Analytical Chemistry, 2020, 92,11420-11428.

[2] Xiaoxue Xie, Zhenqi Peng, Xinyi Hua, Zhifang Wang, Keqin Deng, Xiumei Yang, Haowen Huang*. Selectively monitoring glutathione in human serum and growth-associated living cells using gold nanoclusters, Biosensors and Bioelectronics , 2020, 148, 111829.

[3] Xinyi Hua, Zhichao, Yang, Zhifang, Wang, Xiaoxue Xie, Zaichun Zhou, Xiumei Yang, Keqin Deng, Haowen, Huang*. Rapid modification of hemoglobin heme to form enhanced peroxidase-like activity for colorimetric assay, Biosensors and Bioelectronics: X , 2020, 4, 100041.

[4] Xiaoxue Xie, Zhenqi Peng, Ziqi Wang, Xinyi Hua, Zhifang Wang, Keqin Deng, Xiumei Yang, Haowen Huang*, Xuanyong Liu*. Monitoring biothiols dynamics in living cells by ratiometric fluorescent gold carbon dots, Talanta , 2020, 218, 121214.

[5] Xiaoxue Xie, Fang Tan, Aiqing Xu, Keqin Deng, Yulong Zeng, Haowen Huang*. UV-induced peroxidase-like activity of gold nanoclusters for differentiating pathogenic bacteria and detection of enterotoxin with colorimetric readout, Sensors and Actuators B: Chemical , 2019, 279, 289-297.

[6] Fang Tan, Xiaoxue Xie, Aiqing Xu, Keqin Deng, Yunlong Zeng, Xiumei Yang, Haowen Huang*. Fabricating and regulating peroxidase-like activity of eggshell membrane-templated gold nanoclusters for colorimetric detection of staphylococcal enterotoxin B, Talanta , 2019, 194, 634-642.

[7] Fang Tan, Zhifang Wang, Yan Yang, Xiaoxue Xie, Xinyi Hua, Xiumei Yang, Haowen Huang*. Facile preparation of peroxidase-like core-shell nanorods and application as platform for colorimetric determination of glucose, insulin and glucose/insulin ratio, Talanta , 2019, 204, 285-293

[8] Keqin Deng*, Xinyan Liu, Chunxiang Li, Haowen Huang*. Sensitive electrochemical sensing platform for microRNAs detection based on shortened multi-walled carbon nanotubes with high-loaded thionin, Biosensors and Bioelectronics , 2018, 117, 168-174.

[9] Fang Tan, Yan Yang, Xiaoxue Xie, Linqian Wang, Keqin Deng, Xiaodong Xia, Xiumei Yang, Haowen Huang*. Prompting peroxidase-like activity of gold nanorod composites by localized surface plasmon resonance for fast colorimetric detection of prostate specific antigen, Analyst , 2018, 143, 5038-5045.

[10] Haowen Huang*, Lanfang LiuLingyang ZhangQian ZhaoYuan ZhouShishan YuanZilong TangXuanyong Liu. Peroxidase-Like Activity of Ethylene Diamine Tetraacetic Acid and Its Application for Ultrasensitive Detection of Tumor Biomarkers and Circular Tumor Cells,AnalyticalChemistry, 2017, 8 9 , 666–672.

[11] Qian Zhao, Haowen Huang*, Lingyang Zhang, Linqian Wang, Yunlong Zeng, Xiaodong Xia, Fengping Liu, Yi Chen. Strategy To Fabricate Naked-Eye Readout Ultrasensitive Plasmonic Nanosensor Based on Enzyme Mimetic Gold Nanoclusters,AnalyticalChemistry, 2016, 88 , 1412–1418.

[12] Lingyang Zhang, Donghui Wang, Haowen Huang*, Lanfang Liu, Yuan Zhou, Xiaodong Xia, Keqin Deng, Xuanyong Liu. Preparation of Gold–Carbon Dots and Ratiometric Fluorescence Cellular Imaging，ACS Appl. Mater. Interfaces, 2016, 8 , 6646–6655.

[13] Shenna Chen, Qian Zhao, Fang Liu, Haowen Huang*, Linqian Wang, Shoujun Yi, Yunlong Zeng, and Yi Chen. Ultrasensitive determination of copper in complex biological media based on modulation of plasmonic properties of gold nanorods, Analytical Chemistry, 2013, 85 , 9142–9147.

[14] Haowen Huang*, Shenna Chen, Fang Liu, Qian Zhao, Bo Liao, Shoujun Yi, Yunlong Zeng, Multiplex plasmonic sensor for detection of different metal ions based on single type of gold nanorod, Analytical Chemistry , 2013, 85 , 2312-2319.

[15] Haowen Huang*, Fang Liu, Shenna Chen, Qian Zhao, Bo Liao, Yunfei Long, Yunlong Zeng, Xiaodong Xia, Enhanced fluorescence of chitosan based on size change of micelles and application to directly selective detecting Fe³⁺ in human serum, Biosensors and Bioelectronics , 2013, 42 , 539-

[16] Haowen Huang*, Caiting Qu, Xuanyong Liu, Shaowen Huang, Zhongjian Xu, Yingjie Zhu, Paul K. Chu, Amplification of localized surface plasmon resonance signals by a gold nanorod assembly and ultra-sensitive detection of mercury, Chemical Communications , 2011, 47 , 6897-6899.

[17] Haowen Huang*, Caiting Qu, Xuangyong Liu, Shaowen Huang, Zhongjian Xu, Bo Liao, Yunlong Zeng, Paul. Chu, Preparation of controllable core-shell gold nanoparticles and its application in detection of silver ions, ACS Applied Materials & Interfaces, 2011, 3, 183-190.

代表性專利

[1] 黃昊文，譚芳，謝潇雪，許愛清，鄧克勤，檢測金黃色葡萄球菌及腸毒素B試劑盒的制備方法及應用，發明專利申請号：ZL201710728640.8

[2] 黃昊文，周媛，趙倩，劉蘭芳，張淩陽，一種基于乙二胺四乙酸模拟酶試劑盒的制備方法及其應用，發明專利申請号：201510545849.1。

[3] 黃昊文，張淩陽，劉蘭芳，周媛，一種具有催化性能的碳點制備及基于此碳點試劑盒的應用，發明專利申請号，201510545769.6。